Cognitive decline over 7 years in aging patients with childhood-onset epilepsy: A population-based prospective follow-up study
Our results demonstrate poorer cognitive trajectories in participants with childhood-onset epilepsy compared to controls, particularly in those with active epilepsy. The risk of general cognitive decline was lower in participants with remitted epilepsy, but a decline in episodic memory functions was observed. Our findings likely reflect faster brain aging in childhood-onset epilepsy, even in individuals with early remission.
Authors
- Riitta Parkkola (ORCID: https://orcid.org/0000-0001-8046-315X)
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Petri Tiitta
- Mira Karrasch (ORCID: https://orcid.org/0000-0002-6996-9157)
- Matti Sillanpää (ORCID: https://orcid.org/0000-0003-4190-3698)
- Juho Joutsa (ORCID: https://orcid.org/0000-0002-3457-9415)
- Juha O. Rinne (ORCID: https://orcid.org/0000-0001-6369-0764)
- Tove Roos
Institutions
- Åbo Akademi University (FI)
- University of Wisconsin–Madison (US)
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Varsinais-Suomen Sairaanhoitopiiri (FI)
Publication Details
- Journal
- Journal of the International Neuropsychological Society
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1017/s1355617725101021
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Citizens United for Research in Epilepsy
- Teva Pharmaceutical Industries
- Suomen Lääketieteen Säätiö
- Novo Nordisk
- Turun Yliopisto
- Turun Yliopistollinen Keskussairaala
- H. Lundbeck A/S