Four-Component Selenoazaindolylation-Alkoxylation of Styrenes for the Synthesis of Azaindolyl β-Alkoxyalkyl Selenoethers

Due to the medicinal importance of selenoether and azaindole cores, the design and execution of efficient routes to new compounds bearing these groups placed in juxtaposition with each other are important. Again, multicomponent reactions provide fast and efficient access to the compounds of interest. Herein, we present a one-step route to azaindolyl β-alkoxyalkyl selenoethers or azaindolyl β-hydroxyalkyl selenoethers via the one-step reaction of azaindoles, styrenes, a selenium source, and an alcohol or water using a Ce(IV) oxidant.