Efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis after PICC catheters placement in patients with malignant lymphoma

Objective To investigate the efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis caused by peripherally inserted central catheter(PICC) catheters placement in patients with malignant lymphoma. Methods Ninety patients with malignant lymphoma undergoing PICC catheterization were randomly divided into three groups: the observation group, control group 1 (magnesium sulfate wet compress), and control group 2 (Hirudoid cream application), with 30 cases in each group. The observation group received Lithospermum oil gauze wet compress, control group 1 was treated with 50% magnesium sulfate wet compress, and control group 2 applied Hirudoid cream, all administered twice daily. The incidence and severity grading of phlebitis, as well as vascular protection outcomes (Numeric Rating Scale of pain, resolution time of redness/swelling/pain, and vascular elasticity recovery time), were compared among the three groups. Serum IL-6 and CRP levels were measured before and after intervention. Results The total incidence of phlebitis in the observation group was 6. 67%(2/30), significantly lower than that in control group 1 (33. 33%) and control group 2 (23. 33%) (P＜0. 05). Pain scores (2. 20±0. 25 points), resolution time of redness/swelling/pain (1. 02±0. 15 days), and vascular elasticity recovery time (2. 13±0. 40 days) in the observation group were all superior to those in the control groups (P＜0. 01). Serological markers showed that IL-6 (0. 49±0. 07 ng/L) and CRP (4. 22±3. 20 mg/L) levels in the observation group were significantly lower than those in the control groups (P＜0. 01). Conclusion Lithospermum oil gauze wet compress effectively reduces the incidence of PICC-related mechanical phlebitis, alleviates inflammatory responses, promotes vascular repair, and demonstrates significant clinical value for promotion. (目的 探讨紫草油纱湿敷防治恶性淋巴瘤患者经外周静脉穿刺中心静脉置管(PICC)机械性静脉炎的效果。方法 将90例行PICC置管的恶性淋巴瘤患者随机分为观察组、对照1组(硫酸镁湿敷)和对照2组(喜辽妥软膏), 各30例。观察组采用紫草油纱布湿敷, 对照1组采用50%硫酸镁湿敷, 对照2组采用喜辽妥软膏涂抹, 均2次/d。比较三组机械性静脉炎发生率、严重程度分级及血管保护效果(疼痛评分、红肿/疼痛消失时间、血管弹性恢复时间), 检测干预前后血清白细胞介素-6(IL-6)、超敏C反应蛋白(CRP)水平。结果 观察组发生2(6. 67%)例机械性静脉炎, 低于对照1组10(33. 33%)例和对照2组7(23. 33%)例(P＜0. 05); 观察组数字疼痛评分(NRS)(2. 20±0. 25)分, 红肿疼痛消失时间(1. 02±0. 15)d, 血管弹性恢复时间(2. 13±0. 40)d, 均优于对照组(P＜0. 01)。血清学指标显示, 观察组IL-6(0. 16±0. 10)ng/L, CRP(4. 22±3. 20)mg/L, 均低于对照组(P＜0. 01)。结论 紫草油纱布湿敷能有效降低PICC置管后并发机械性静脉炎发生率, 缓解炎症反应, 促进血管修复, 具有临床推广价值。)