Formulation and physical evaluation of Gnetum gnemon L. peel extract tablets using variation concentration of Na-CMC and starch 1500

Gnetum gnemon L. peel extract contains flavonoid compounds, which are used to lower cholesterol levels. It needs to be formulated into tablets to maximize the potential of the Gnetum gnemon L. peel extract. This research aims to determine the effect of variations in Na-CMC and starch 1500 concentrations on the physical properties of granules and tablets. The method used was wet granulation, using variations in Na-CMC and starch 1500 concentrations Formula 1 (5%: 6%), Formula 2 (3%: 8%), and Formula 3 (1%: 10%). The evaluation included the physical properties of granules (flow rate, angle of repose, compressibility) and the physical properties of tablets (organoleptic, weight uniformity, hardness, friability, and disintegration time). The data obtained were then analyzed statistically. The results showed that the addition of Na-CMC binder and starch 1500 disintegrant affected the granules and tablets. Formula 1 produces granules and tablets with better physical properties compared to Formula 2 and Formula 3. This research concludes that the concentration of Na-CMC and starch 1500 affects the physical properties and Formula 1 is the best formula with a ratio of Na-CMC (5%) and starch 1500 (6%).