Impact of old and current immunoassays on the 1 mg overnight dexamethasone suppression test: comparison with LC-MS/MS
Both immunoassays demonstrated remarkable underdetection of hypercortisolism, suggesting the application of a method-specific cutoff. Immunoassay performance may not be uniform in basal and post-DST conditions and should be purposely examined. Accurate LC-MS/MS methods should be preferred in hypercortisolism settings.
Authors
- Flaminia Fanelli (ORCID: https://orcid.org/0000-0003-2601-2694)
- Guido Di Dalmazi (ORCID: https://orcid.org/0000-0002-1291-8906)
- Valentina Bissi
- Laura Rotolo
- Valentina Vicennati (ORCID: https://orcid.org/0000-0002-0026-137X)
- Alessandra Gambineri (ORCID: https://orcid.org/0000-0003-2242-6734)
- Lorenzo Tucci (ORCID: https://orcid.org/0000-0002-1670-0074)
- Uberto Pagotto (ORCID: https://orcid.org/0000-0003-4182-3110)
- Greta Galante
- Kimberly Coscia
- Marco Mezzullo (ORCID: https://orcid.org/0000-0001-6748-3041)
- Guido Zavatta (ORCID: https://orcid.org/0000-0003-3657-2070)
Institutions
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-06-30
- DOI
- https://doi.org/10.1093/ejendo/lvaf141
- Citations
- 4
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- Regione Emilia-Romagna