Differences in inflammation biomarkers between patients with paroxysmal and persistent atrial fibrillation in the femoral vein and coronary sinus blood samples; a cohort study
This study supports the involvement of TNFSF-14, IL-6, and IL-18 in the pathogenesis and maintenance of PeAF. Furthermore, it identifies β-NGF and TGF-α as potential participants in the pathogenesis and/or maintenance of PeAF locally in the atria. Novel inflammatory biomarkers, mainly chemokines, are also identified as possibly involved in the pathophysiology of AF.
Authors
- Carl‐Johan Carlhäll (ORCID: https://orcid.org/0000-0003-2198-9690)
- Emmanouil Charitakis (ORCID: https://orcid.org/0000-0002-2514-5324)
- Johan Lindbäck (ORCID: https://orcid.org/0000-0002-6473-8798)
- Lars Karlsson (ORCID: https://orcid.org/0000-0003-4852-3065)
- Ziad Hijazi (ORCID: https://orcid.org/0000-0002-7420-743X)
- Carlos Valera Soria
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Linköping University Hospital (SE)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1093/ehjopen/oeaf089
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Hjärt-Lungfonden
- Akademiska Sjukhuset
- Uppsala Universitet