Mosaic Loss of Y Chromosome Defines a Proximal Tubular Cell State Associated with Recovery from DGF and of Allograft Quality and Functional Reserve Post DCD Kidney Transplantation
Taken together, our dataset of serial biopsies from DCD kidney transplants reveals insights into mechanisms driving injury and repair in the setting of DGF and offers a signature of allograft quality and functional reserve that may optimize allocation at the time of procurement.
Authors
- Rohan Paul (ORCID: https://orcid.org/0000-0002-6733-1766)
- Amber Reeves‐Daniel
- Mohammad Kazem Fallahzadeh (ORCID: https://orcid.org/0000-0002-7348-3504)
- Andrew F. Malone (ORCID: https://orcid.org/0000-0002-2997-7531)
- John R. Savino
- Alejandra Mena‐Gutierrez
- Haikuo Li (ORCID: https://orcid.org/0000-0003-3697-5662)
- Huw Davies
- Robert J. Stratta (ORCID: https://orcid.org/0000-0001-7634-094X)
- Giuseppe Orlando (ORCID: https://orcid.org/0000-0002-6460-7974)
- Lori N. Byers
- Nicolas Ledru (ORCID: https://orcid.org/0000-0002-9237-3634)
- Benjamin D. Humphreys (ORCID: https://orcid.org/0000-0002-6420-8703)
- Alexandra R. Monetti
- Gwen McPherson
- Amish Asthana (ORCID: https://orcid.org/0000-0002-4597-5982)
- Emily McCracken (ORCID: https://orcid.org/0000-0001-8138-2239)
- Christopher Webb (ORCID: https://orcid.org/0000-0002-5654-2250)
- Travis C Doty
- Alexei Mikhailov (ORCID: https://orcid.org/0000-0002-5695-129X)
- Colleen L. Jay (ORCID: https://orcid.org/0000-0003-2552-2617)
- Hao Wu (ORCID: https://orcid.org/0000-0002-7866-2544)
- Aidan Leckie-Harre
- Steve J. Walker
- Alan C. Farney
- Natalia V. Sakhovskaja
Institutions
- Forest Institute (US)
- Atrium Health Wake Forest Baptist (US)
- Winston-Salem State University (US)
- Washington University in St. Louis (US)
- St. Vincent's University Hospital (IE)
- Winston-Salem/Forsyth County Schools (US)
- Ospedale San Giuseppe (IT)
- Wake Forest University (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/sla.0000000000006830
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00