Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from <i>Sappan lignum</i>
Sappanumols A-C (<b>1</b>-<b>3</b>, respectively), three unprecedented homoisoflavonoids, were isolated from <i>Sappan lignum</i>. Their structures were elucidated by comprehensive spectroscopic analysis and ECD computation methods. Compound <b>3</b> demonstrated inhibitory effects on LPS-induced NO production in BV-2 cells with an IC<sub>50</sub> value of 16.99 <i>μ</i>M. Compound <b>3</b> decreased the levels of TNF-α and IL-6 in a dose-dependent manner and exhibited significant anti-inflammatory activity in a zebrafish inflammation model.
Authors
- Hong Chen (ORCID: https://orcid.org/0000-0002-5102-6302)
- Jun Lin (ORCID: https://orcid.org/0000-0002-2087-6013)
- Ke‐Wu Zeng (ORCID: https://orcid.org/0000-0003-1082-6327)
- Haojie Liu (ORCID: https://orcid.org/0000-0002-2595-6012)
- Qi‐Qi Wang (ORCID: https://orcid.org/0000-0002-6588-8763)
- Yue Shen
- Guo‐Qing Qin (ORCID: https://orcid.org/0009-0005-2925-7154)
- Ping Yang (ORCID: https://orcid.org/0000-0003-4074-2423)
- Qingying Zhang
- Pengfei Tu (ORCID: https://orcid.org/0000-0002-3848-8174)
Institutions
- Qilu University of Technology (CN)
- Beijing University of Chinese Medicine (CN)
- Peking University (CN)
- Shandong Academy of Sciences (CN)
- State Key Laboratory of Natural and Biomimetic Drugs (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c02020
- Citations
- 2
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 2.79