History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment
Moderate-to-severe chronic pain intensity and interference related to executive function decline and greater risk of non-amnestic MCI; while opioid use related to verbal fluency decline and greater risk of amnestic MCI. Lowering chronic pain severity while reducing opioid exposure may help clinicians mitigate later cognitive decline and dementia risk.
Authors
- Mark Sanderson‐Cimino (ORCID: https://orcid.org/0000-0002-5872-3186)
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- McKenna E. Williams (ORCID: https://orcid.org/0000-0002-4106-5025)
- Amy J. Jak (ORCID: https://orcid.org/0000-0001-8588-1430)
- Chandra A. Reynolds (ORCID: https://orcid.org/0000-0001-6502-7173)
- Daniel E. Gustavson (ORCID: https://orcid.org/0000-0002-1470-4928)
- Rosemary Toomey (ORCID: https://orcid.org/0000-0001-5981-6934)
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Rahul C. Pearce
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Matthew S. Panizzon (ORCID: https://orcid.org/0000-0002-6449-2097)
Institutions
- Boston University (US)
- University of Colorado Boulder (US)
- University of Colorado System (US)
- University of California San Diego (US)
- University Memory and Aging Center (US)
- Center for Neurosciences (US)
Publication Details
- Journal
- Journal of the International Neuropsychological Society
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1017/s1355617725101057
- Citations
- 2
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 2.79