Atomically Precise Au<sub>32</sub> Clusters for 3D Visualization of Pathological Progression in Sepsis-Induced Multi-Organ Injury

Sepsis has a high global incidence and mortality, requiring early identification and assessment of organ damage. We present a NIR-II 3D visualization strategy using atomically precise fluorescent Au<sub>3</sub><sub>2</sub> clusters to detect sepsis-induced multi-organ injury. These clusters emit strong fluorescence at 1044 nm with extended photostability (up to 300 min). Integrated with light-sheet microscopy, the method achieves rapid 3D imaging with a 2 μm isotropic resolution and 500 μm tissue penetration. It reveals significant pathological changes in two sepsis models, including intestinal villi shortening (to 32.7% and 43.8%) and renal tubule swelling (1.9× and 2.1×). Blood vessel integrity in pulmonary bronchioles was reduced to 37.1% and 45.2%. This approach enables detailed visualization of microstructural lesions and disease progression, underscoring its potential for early diagnosis and monitoring of sepsis-induced organ injury.

Authors

Institutions

Publication Details

Journal
Nano Letters
Published
2025-07-14
DOI
https://doi.org/10.1021/acs.nanolett.5c02725
Citations
8
Primary Topic
Nanocluster Synthesis and Applications
Type
article
Field-Weighted Citation Impact
4.14
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Atomically Precise Au32 Clusters for 3D Visualization of Pathological Progression in Sepsis-Induced Multi-Organ Injury

Shuyu Yang, Yuxing Yan, Huizhen Ma, Yuanlian Huo et al.
8 citations
Nano Letters
Nanocluster Synthesis and Applications
4.14
article

Atomically Precise Au32 Clusters for 3D Visualization of Pathological Progression in Sepsis-Induced Multi-Organ Injury

Shuyu Yang, Yuxing Yan, Huizhen Ma, Yuanlian Huo, Xiaodong Zhang, Ling Liu, Shasha Li, Zili Zhang, Shibo Li, Hao Wang, Xin Qi, Jing-Jing Zang, Pengfei Liu, Kefeng Jia, Haoyue Yan, Di Ma, Siyu Ao
article en
8 citations

Abstract

Sepsis has a high global incidence and mortality, requiring early identification and assessment of organ damage. We present a NIR-II 3D visualization strategy using atomically precise fluorescent Au<sub>3</sub><sub>2</sub> clusters to detect sepsis-induced multi-organ injury. These clusters emit strong fluorescence at 1044 nm with extended photostability (up to 300 min). Integrated with light-sheet microscopy, the method achieves rapid 3D imaging with a 2 μm isotropic resolution and 500 μm tissue penetration. It reveals significant pathological changes in two sepsis models, including intestinal villi shortening (to 32.7% and 43.8%) and renal tubule swelling (1.9× and 2.1×). Blood vessel integrity in pulmonary bronchioles was reduced to 37.1% and 45.2%. This approach enables detailed visualization of microstructural lesions and disease progression, underscoring its potential for early diagnosis and monitoring of sepsis-induced organ injury.

Nano LettersVol. 25(29)
Tianjin University (CN), Shanxi Medical University (CN), Tianjin Central Hospital of Gynecology Obstetrics (CN), Advanced Materials and Devices (United States) (US), Office of Basic Energy Sciences (US)
Openalex Percentile: Top 5%
Nanocluster Synthesis and Applications
4.14
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.