Promotion of HIV clearance by sensitization of HIV reservoirs to cell death
Our results indicate that T cell reservoirs refractory to depletion maintain a delicate balance between low levels of HIV gene expression and evasion of cell death. This study suggests that targeting epigenetic repression of HIV is critical for the depletion of the viral reservoirs.
Authors
- Laurie J. Minze (ORCID: https://orcid.org/0000-0002-1430-1846)
- Bai-chao Sun (ORCID: https://orcid.org/0000-0002-6992-3626)
- Jin Wang (ORCID: https://orcid.org/0000-0002-3116-0838)
- Min Li (ORCID: https://orcid.org/0000-0002-1220-062X)
- Jiànróng Lǐ (ORCID: https://orcid.org/0000-0002-7130-1084)
- Jing Dong (ORCID: https://orcid.org/0000-0003-2693-9924)
- Min Chen (ORCID: https://orcid.org/0000-0002-9699-7524)
- Chao Cheng (ORCID: https://orcid.org/0000-0002-9380-3296)
Institutions
- Houston Methodist (US)
- Baylor College of Medicine (US)
- Cornell University (US)
- Houston Institute for Clinical Research (US)
- Children's Cancer Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1600741
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health