Plasma circulating microRNAs and symptoms of depression: Results from a population‐based study
This study proposes several circulating miRNAs that may be associated with depressive symptoms within the general population. Our follow-up analyses indicate that the miRNAs with the largest effect estimates were potentially involved in neurological and psychiatric processes, warranting further investigation into their potential role in the biological mechanisms of depression. These results provide preliminary insights and should be considered exploratory and hypothesis-generating, warranting validation in future studies with larger and independent cohorts.
Authors
- Annemarie I. Luik (ORCID: https://orcid.org/0000-0001-7517-197X)
- Charlotte A. M. Cecil (ORCID: https://orcid.org/0000-0002-2389-5922)
- Alexander Neumann (ORCID: https://orcid.org/0000-0001-6653-3203)
- Mohsen Ghanbari (ORCID: https://orcid.org/0000-0002-9476-7143)
- Midas M. Kuilman
- M Arfan Ikram
- Tim Finke
Institutions
- Erasmus MC (NL)
- Trimbos Institute (NL)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1111/pcn.13869
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- ZonMw
- Erasmus Universiteit Rotterdam
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland
- Janssen Prevention Center