Clinicopathological and genetic analysis of orbital solitary fibrous tumors
Orbital SFT were found in younger cohorts and smaller in size than other SFT. STAT6, CD99, GRIA2, ALDH1, CD34, and Bcl-2 are sensitive indications for orbital SFT, while CD99, ALDH1 and CD34 are more sensitive. High Bcl-2 expression is more common in primary and benign orbital SFT. The orbital SFT gene fusion variants include NAB2ex4-STAT6ex2, NAB2ex6-STAT6ex16, NAB2ex6-STAT6ex17, and NAB2ex7-STAT6ex4. An in-depth clinicopathological study can help explain orbital SFT.
Authors
- Jinzhi Zhao
- Emmanuel Eric Pazo (ORCID: https://orcid.org/0000-0002-0848-827X)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-9580-0136)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Qing Wang (ORCID: https://orcid.org/0000-0003-3911-9992)
- Tingting Lin (ORCID: https://orcid.org/0000-0002-6061-2311)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Tianming Jian (ORCID: https://orcid.org/0000-0001-6377-0254)
- Zonghan Nan
Institutions
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s12886-025-04223-4
- Citations
- 2
- Primary Topic
- Soft tissue tumor case studies
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Tianjin Medical University
- Tianjin Medical University Eye Hospital