Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway
This study presents a novel FA-PPI-Ms delivery system for targeted macrophages. By modulating polarization through inhibition of JAK2/STAT3 signaling, the system offers a promising therapeutic strategy for RA and potentially other inflammatory diseases.
Authors
- Ruibo Guo
- Yang Yu (ORCID: https://orcid.org/0000-0002-8141-0081)
- Xuetao Li (ORCID: https://orcid.org/0000-0002-0608-4669)
- Liang Kong (ORCID: https://orcid.org/0000-0002-5721-0290)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8079-8638)
- Xiuying Li (ORCID: https://orcid.org/0000-0003-2686-1426)
- Shutong Li (ORCID: https://orcid.org/0000-0001-7228-547X)
- Yang Liu (ORCID: https://orcid.org/0000-0003-4350-8448)
- Yani Zhang (ORCID: https://orcid.org/0000-0002-4028-5448)
- Feng-yuan Zhang
Institutions
- Shanxi University (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Shenyang University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s12951-025-03576-8
- Citations
- 10
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China