Association of genetic variants of hemostasis system genes with pregnancy loss in women

Abstract Background Venous thrombosis may be the cause of a complicated obstetric and gynecological history in women. One of the types of disorders in the hemostasis system is gestational thrombophilia, which can lead to various pregnancy complications. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors. The aim of our work Is to analyze the association of eight genetic variants (F2 20210G > A, F5 1691G > A, F7 10976G > A, F13 G > T, ITGA2 807C > T, ITGB3 1565 T > C, PAI-1 -675 5G > 4G) of the hemostasis system genes in women with pregnancy loss. Design and methods. The study included 311 women aged 20 to 38 years, who have had at least one pregnancy end in miscarriage, and 225 women in the control group. The study of the genotypes of the selected genetic variants was carried out by real-time PCR with melting curve analysis. Results A positive association was found for 4 genetic variants: F2: 20,210 G > A (OR = 11.03, CI 2.60–46.81, P < 0.001); F5 1691G > A (OR = 6.02, CI 2.52–14.38, P < 0.001); FGB: -455 G > A (OR = 5.65, CI 3.05–10.45, P < 0.001) and PAI-1 -675 5G > 4G (OR = 2.28, CI 1.54–3.39, P < 0.001). Conclusion Thus, we established an association of four genetic variants of plasma hemostatic factor genes with pregnancy loss in women.