A possible role of urinary genotoxic Escherichia coli in prostate cancer in Nigerian patients

The frequency of E. coli was 36.0% of prostate cancer patients and 30.0% of controls, respectively (p = 0.557). Furthermore, there was a higher occurrence of the clb gene in cases compared to controls (36.4% vs. 8.3%). Cytolethal distending toxin (cdt) gene was absent in all isolates examined. The analysis revealed no significant relationship between the selected genotoxins and prostate cancer (p = 0.104). The Gleason grade of the cancer was not a major determinant in the occurrence of clb within the cancer cases. The present study is the first report investigating bacterial genotoxins in urine samples of Nigerian prostate cancer patients. Our findings showed no association between bacterial genotoxins and prostate cancer. Additional investigations are warranted to further investigate the role of bacterial genotoxins in prostate cancer development.