Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels
The IFNG-AS1 variants rs4913269 and rs7134599 exert opposing effects on Lg-CL risk and modulate key cytokines involved in disease pathogenesis. These findings underscore the regulatory role in immune responses and increase our understanding of the immunogenetic basis of CL and support the potential IFNG-AS1 as a biomarker for susceptibility.
Authors
- Aya Sadahiro (ORCID: https://orcid.org/0000-0002-3148-8163)
- Krys Layane Guimarães Duarte Queiroz
- Marcus Vinítius de Farias Guerra
- José do Espírito Santo (ORCID: https://orcid.org/0000-0002-7922-6090)
- Josué Lacerda de Souza (ORCID: https://orcid.org/0009-0003-0596-8010)
- George Silva (ORCID: https://orcid.org/0000-0001-9803-1996)
- Mara Lúcia Gomes de Souza (ORCID: https://orcid.org/0000-0002-4273-2678)
- Maurício Morishi Ogusku (ORCID: https://orcid.org/0000-0003-0173-6266)
- Tirza Gabrielle Ramos de Mesquita (ORCID: https://orcid.org/0000-0001-5896-1005)
- Lener Santos da Silva
- Rajendranath Ramasawmy (ORCID: https://orcid.org/0000-0002-0538-0773)
- José Pereira de Moura Neto (ORCID: https://orcid.org/0000-0003-2177-7292)
Institutions
- Instituto Nacional de Pesquisas da Amazônia (BR)
- Fundação de Medicina Tropical (BR)
- Universidade Nilton Lins (BR)
- Universidade do Estado do Amazonas (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1371/journal.pntd.0013318
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Amazonas