Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene
A halofluorocarbon, chromatography-free synthesis on the GE FX<sub>FN</sub> module afforded difluorocarbene reagent [<sup>18</sup>F]10 in 10.1% ± 1.9% RCY (decay-corrected). Additionally, a fully-automated three-step [<sup>18</sup>F]difluorocarbene insertion radiosynthesis using two tandem FX<sub>FN</sub>s is described for the first time, providing a path forward to the full automation of [<sup>18</sup>F]difluorocarbene insertion on two-reactor systems.
Authors
- Franklin I. Aigbirhio (ORCID: https://orcid.org/0000-0001-9453-5257)
- Alan M. Bond (ORCID: https://orcid.org/0000-0002-1113-5205)
- Selena Milicevic Sephton (ORCID: https://orcid.org/0000-0002-1105-6726)
- Catherine G F Dickmann
Institutions
- University of Cambridge (GB)
- Imaging Center (US)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s41181-025-00353-8
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Alzheimer’s Research UK
- NIHR Cambridge Biomedical Research Centre