PNP-Mn(I) Catalyzed Base Free <i>N</i>-Alkylation of Amines Using Alcohols
We report a Mn(I) pincer complex, [Mn(CO)<sub>3</sub>{<i>o</i>-Ph<sub>2</sub>PC<sub>6</sub>H<sub>4</sub>C(O)N(C<sub>6</sub>H<sub>4</sub>PPh<sub>2</sub>-<i>o</i>)}κ<sup>3</sup>-<i>P</i>,<i>N</i>,<i>P</i>], bearing an amide-functionalized bisphosphine (BalaHariPhos), for the efficient <i>N</i>-alkylation of amines with alcohols. The reaction proceeds under base-free conditions at 80 °C, affording <i>N</i>-alkylated products in good to excellent yields within 12 h. Broad substrate scope is demonstrated, including the synthesis of indoles and dibenzyl piperazine. Selective mono-<i>N</i>-methylation of amines using methanol as a C<sub>1</sub> source was also achieved. This work establishes a sustainable, non-noble metal platform for amine functionalization.
Authors
- Maravanji S. Balakrishna (ORCID: https://orcid.org/0000-0003-3736-6148)
- Rani Gourkhede
Institutions
- Indian Institute of Technology Bombay (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c02186
- Citations
- 2
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.07