Progressive Hyperglycemia in Tolerant Miniature Swine Recipients of Composite Islet-kidney Grafts Is not due to Islet Loss but Rather to Increased Insulin Demand With Growth
These findings indicate that loss of function of a vascularized IK graft with time is likely due to increased insulin demand in a growing animal and not due to islet loss.
Authors
- Yoshinori Ishikawa (ORCID: https://orcid.org/0000-0001-6697-4527)
- Adam Griesemer (ORCID: https://orcid.org/0000-0003-4894-2024)
- Prashanth Vallabhajosyula (ORCID: https://orcid.org/0000-0002-1192-3367)
- David H. Sachs (ORCID: https://orcid.org/0000-0001-9588-8580)
- Joshua Weiner (ORCID: https://orcid.org/0000-0003-3780-1875)
- Ishit Chauhan
- Kazuhiko Yamada (ORCID: https://orcid.org/0000-0002-0510-5843)
- Atsushi Hirakata (ORCID: https://orcid.org/0000-0001-8195-5164)
- Nathaly Llore
Institutions
- Columbia University Irving Medical Center (US)
- NYU Langone Health (US)
- Massachusetts General Hospital (US)
- Presbyterian Hospital (US)
- Miami Transplant Institute (US)
- Columbia University (US)
Publication Details
- Journal
- Transplantation
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/tp.0000000000005447
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00