Microecology and oral immune defense during exercise as factors for local and systemic inflammation

Relevance of the research topic is related to the fact of increased young athletes morbidity, determined by hormonal changes of the pubescent period and a decrease in immunity with excessive or inadequate physical exertion. Objective of the study is to substantiate the need to support the immunological reserves of young athletes using medicines based on the assessment of factors of innate immunity – lysozyme and lactoferrin. Material and methods. A systematic review was conducted in foreign and domestic databases over the past ten years, including Medline www.ncbi.nlm.nih .gov; Russian scientific database elibrary https://www.elibrary.ru, Cochrane Library (The Cochrane Central Register of Controlled Trials (CENTRAL) www.thecochranelibrary.com. Results. Аnalysis of the literature showed a decrease in immunological parameters, including factors of innate immunity lysozyme and lactofferin under high physical exertion in young athletes, which leads to the development of focal inflammatory processes in the entrance gate of infection. The consequence of these processes in the future is the possible development of somatic comorbid pathology. Conclusion. The prevention of the spread of local infection in the oral cavity, nose and throat in young athletes is necessary with analogues of natural local immunity factors to maintain protection – lysozyme and transferrin.