Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression
Our findings indicate differences in brain functional neural organization associated with apathy and depression, underscoring the importance of distinguishing these symptoms in ALS and highlighting the need for targeted interventions.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Veronica Castelnovo
- Elisa Canu (ORCID: https://orcid.org/0000-0001-5804-3378)
- Edoardo Gioele Spinelli (ORCID: https://orcid.org/0000-0003-1492-7221)
- Federica Agosta (ORCID: https://orcid.org/0000-0003-3121-4979)
- Vincenzo Silani (ORCID: https://orcid.org/0000-0002-7698-3854)
- Ildebrando Marco Appollonio (ORCID: https://orcid.org/0000-0003-4717-6479)
- Silvia Torre (ORCID: https://orcid.org/0000-0002-2039-3644)
- Tommaso Russo (ORCID: https://orcid.org/0000-0003-4426-0106)
- Federico Verde (ORCID: https://orcid.org/0000-0002-3977-6995)
- Yuri Falzone (ORCID: https://orcid.org/0000-0003-3233-1907)
- Barbara Poletti (ORCID: https://orcid.org/0000-0003-4398-2051)
- Lucio Tremolizzo
- Paride Schito (ORCID: https://orcid.org/0000-0002-7152-4472)
- Silvia Basaia (ORCID: https://orcid.org/0000-0002-0722-6243)
- Nicola Ticozzi
- Fabiola Freri
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ferrari (Italy) (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1007/s00415-025-13247-1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Fondazione Italiana Sclerosi Multipla
- EU Joint Programme – Neurodegenerative Disease Research
- E-Rare
- Ministero della Salute
- Novo Nordisk
- Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
- Ministero dell'Università e della Ricerca
- Novartis Pharma
- H2020 European Research Council