CRISPR-mediated proximity labeling unveils ABHD14B as a host factor to regulate HBV cccDNA transcriptional activity
ABHD14B was newly identified as a suppressor of HBV RNA transcription from cccDNA, which may improve our understanding of the mode of existence of cccDNA, providing a basis for development of a functional cure.
Authors
- Takahiro Seimiya (ORCID: https://orcid.org/0000-0003-1698-0309)
- Chikako Shibata (ORCID: https://orcid.org/0000-0001-9492-3794)
- Yu Miyakawa
- Takahiro Kishikawa (ORCID: https://orcid.org/0000-0002-8602-5916)
- Nozomi Miyake
- Mitsuhiro Fujishiro (ORCID: https://orcid.org/0000-0002-4074-1140)
- Motoyuki Otsuka (ORCID: https://orcid.org/0000-0003-2869-2881)
- Kazuma Sekiba (ORCID: https://orcid.org/0000-0002-9429-1974)
Institutions
- Okayama University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/hc9.0000000000000757
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35