ORP2 regulates free cholesterol accumulation in hepatocytes during MASH
Our results suggest that impaired cholesterol trafficking may exacerbate the deposition of cholesterol crystals in hepatocytes, promoting the development of metabolic dysfunction-associated steatohepatitis.
Authors
- Liwen Qiu
- Yang Liu (ORCID: https://orcid.org/0000-0002-4428-3562)
- Yan Liang (ORCID: https://orcid.org/0000-0001-9747-4357)
- Feng‐Jung Chen (ORCID: https://orcid.org/0000-0002-0041-003X)
- Jin Wu (ORCID: https://orcid.org/0000-0001-9926-0993)
- Yingjie Zhang (ORCID: https://orcid.org/0000-0002-4170-6152)
- Daiwen Chen (ORCID: https://orcid.org/0000-0002-8351-7421)
- Hongyu Wang
- Xiaowei Wang (ORCID: https://orcid.org/0009-0008-2900-5207)
- Hongyuan Yang
- Qiaoli Chen (ORCID: https://orcid.org/0000-0002-0102-1351)
- Mingming Gao (ORCID: https://orcid.org/0000-0001-6265-1181)
- Jingwen Gu (ORCID: https://orcid.org/0000-0003-2258-3131)
- Xiaoqin Wu
- Yudi Zhao (ORCID: https://orcid.org/0000-0002-8663-5845)
Institutions
- Hebei Medical University (CN)
- The University of Texas MD Anderson Cancer Center (US)
- Fudan University (CN)
- UNSW Sydney (AU)
- Nanjing Drum Tower Hospital (CN)
- Model Animal Research Center (CN)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/hc9.0000000000000737
- Citations
- 1
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.01