METTL3 inhibits liver fibrosis via RBX1 stability and TXNIP-mediated ferroptosis
This study underscores the essential role of TXNIP in the progression of liver fibrosis and suggests that a therapeutic strategy targeting TXNIP ubiquitination-mediated autophagy-dependent ferroptosis could offer a novel approach to treating liver fibrosis. The insights gained from this research provide a solid foundation for the development of innovative therapeutic interventions.
Authors
- Likun Liu (ORCID: https://orcid.org/0000-0001-7013-7457)
- Yue Yu (ORCID: https://orcid.org/0000-0002-7622-7362)
- Fang Gu (ORCID: https://orcid.org/0009-0004-2126-7107)
- Yilin Luo (ORCID: https://orcid.org/0009-0004-8195-3184)
- Xin Liao (ORCID: https://orcid.org/0000-0003-4084-645X)
- Jinhui Du
Institutions
- Guiyang Medical University (CN)
- Qualcomm (United Kingdom) (GB)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/hc9.0000000000000752
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42