Evaluating a triaza-18-crown-6 picolinate chelator for [ <sup>212/203</sup> Pb]Pb <sup>2+</sup> and [ <sup>212/213</sup> Bi]Bi <sup>3+</sup> theranostics
H<sub>3</sub>tripa (H<sub>3</sub>macrotripa), a triaza-18-crown-6 macrocycle bearing three picolinate arms, enables quantitative radiolabeling of [<sup>203</sup>Pb]Pb<sup>2+</sup> and [<sup>213</sup>Bi]Bi<sup>3+</sup> and exhibits robust human serum stability. NMR spectroscopy, X-ray crystallography, density functional theory, and UV-potentiometry investigate its coordination geometry and thermodynamics with Bi<sup>3+</sup> and Pb<sup>2+</sup>, highlighting H<sub>3</sub>tripa as a promising Pb/Bi theranostic chelator.
Authors
- Desiree Fiaccabrino (ORCID: https://orcid.org/0000-0001-5152-4611)
- Brooke L. McNeil (ORCID: https://orcid.org/0000-0002-7376-0647)
- Chris Orvig (ORCID: https://orcid.org/0000-0002-2830-5493)
- Marı́a de Guadalupe Jaraquemada-Peláez (ORCID: https://orcid.org/0000-0002-6204-707X)
- Paul Schaffer
- Brian O. Patrick (ORCID: https://orcid.org/0000-0002-2921-8439)
- Tinotenda Rose Masvikeni
Institutions
- TRIUMF (CA)
- University of British Columbia (CA)
- Simon Fraser University (CA)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5dt01103e
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36