Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer
ARID1A mutations regulate expression of alanine transporters to control alanine distribution between cancer cells and the associated tumor microenvironment, which may be exploited therapeutically alone or in combination with immunotherapy.
Authors
- Amir A. Jazaeri (ORCID: https://orcid.org/0000-0003-4335-4151)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6736-2781)
- Wei Zhou (ORCID: https://orcid.org/0000-0001-9607-4490)
- Liping Liao (ORCID: https://orcid.org/0000-0002-8430-1956)
- Jared K. Burks (ORCID: https://orcid.org/0000-0002-6173-9074)
- Shengqing Gu (ORCID: https://orcid.org/0000-0002-4200-0864)
- Hao Nie (ORCID: https://orcid.org/0000-0002-8985-1279)
- Ernst Lengyel (ORCID: https://orcid.org/0000-0001-8624-1507)
- Federica Severi (ORCID: https://orcid.org/0000-0002-7269-0958)
- Lin Tan (ORCID: https://orcid.org/0000-0001-5156-7814)
- Philip L. Lorenzi (ORCID: https://orcid.org/0000-0003-0385-7774)
- Aaron R. Goldman (ORCID: https://orcid.org/0000-0001-7605-9592)
- Agnes Julia Bilecz (ORCID: https://orcid.org/0000-0002-5231-2669)
- Ronny Drapkin (ORCID: https://orcid.org/0000-0002-6912-6977)
- Javier A. Gomez (ORCID: https://orcid.org/0000-0002-6579-744X)
- Taito Miyamoto (ORCID: https://orcid.org/0000-0001-7453-1611)
- Daniel T. Claiborne (ORCID: https://orcid.org/0000-0002-2091-1456)
- Rugang Zhang (ORCID: https://orcid.org/0000-0002-7255-2360)
- Erin H. Seeley (ORCID: https://orcid.org/0000-0002-8000-5754)
- Heng Liu (ORCID: https://orcid.org/0000-0002-7878-4998)
- Eyal Gottlieb (ORCID: https://orcid.org/0000-0002-9770-0956)
- Shuai Wu (ORCID: https://orcid.org/0000-0002-3183-5081)
- Yuan Qi (ORCID: https://orcid.org/0000-0001-9718-7593)
- Anil K. Sood (ORCID: https://orcid.org/0000-0003-4242-1762)
- Rafał Zieliński (ORCID: https://orcid.org/0000-0001-5735-9119)
- Chen Wang (ORCID: https://orcid.org/0000-0002-9803-1483)
Institutions
- The Wistar Institute (US)
- City Of Hope National Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Chinese Academy of Sciences (CN)
- Kyoto University (JP)
- University of Chicago (US)
- Shanghai Institute of Materia Medica (CN)
- University of Pennsylvania (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0654
- Citations
- 2
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61