A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Characterization of the molecular mechanisms of VISTA and elucidation of therapeutic vulnerabilities in a class of triple-negative breast cancer that strongly expresses VISTA in tumor cells could inform future immune-targeting anticancer therapies. See related commentary by Tao and Vasan, p. 3371.
Authors
- James M. Ford (ORCID: https://orcid.org/0000-0002-2513-7025)
- Idit Sagiv-Barfi (ORCID: https://orcid.org/0000-0002-8372-9096)
- Ishrat Durdana (ORCID: https://orcid.org/0009-0003-5810-6502)
- Tao Yue (ORCID: https://orcid.org/0000-0001-5417-2826)
- Harsh Goar (ORCID: https://orcid.org/0000-0002-0759-613X)
- Michael Snyder (ORCID: https://orcid.org/0000-0003-0784-7987)
- Caiden J. Golder (ORCID: https://orcid.org/0000-0002-0306-4793)
- Joshua James Gruber (ORCID: https://orcid.org/0000-0002-8642-6074)
- Dipti Thakkar (ORCID: https://orcid.org/0009-0004-9947-3779)
- Benjamin S. Geller (ORCID: https://orcid.org/0000-0003-3497-6186)
- Kristina Paul (ORCID: https://orcid.org/0000-0003-0767-4617)
- Chieh‐Yu Lin (ORCID: https://orcid.org/0000-0002-4269-3234)
- Robert B. West (ORCID: https://orcid.org/0000-0002-8330-8283)
- Marisa M. Juntilla (ORCID: https://orcid.org/0000-0003-0872-9341)
- Melinda L. Telli (ORCID: https://orcid.org/0000-0001-7993-1235)
- Soo‐Ryum Yang (ORCID: https://orcid.org/0000-0002-1051-502X)
- Andrew M. Lipchik (ORCID: https://orcid.org/0000-0003-4702-4504)
- Yan Zhao (ORCID: https://orcid.org/0000-0003-3003-2890)
- Allison W. Kurian (ORCID: https://orcid.org/0000-0002-6175-9470)
- Jerome D. Boyd‐Kirkup (ORCID: https://orcid.org/0000-0002-6033-2619)
- Yan Shen Peng (ORCID: https://orcid.org/0000-0001-5765-6260)
- Song Zhang (ORCID: https://orcid.org/0000-0002-9364-4053)
- Stephen Moore (ORCID: https://orcid.org/0000-0003-4156-5350)
- T Andoh (ORCID: https://orcid.org/0009-0004-9653-9736)
- Ashley N. Hardy
- Priyanka Reddy (ORCID: https://orcid.org/0009-0006-4002-6020)
- Fatima Charles
Institutions
- Eugene Applebaum College of Pharmacy and Health Sciences (US)
- Wayne State College (US)
- Memorial Sloan Kettering Cancer Center (US)
- Palo Alto University (US)
- Wayne State University (US)
- Washington University in St. Louis (US)
- Southwestern Medical Center (US)
- Guardant (United States) (US)
- Waseda Bioscience Research Institute in Singapore (SG)
- Stanford Medicine (US)
- Bluebird Bio (United States) (US)
- Organogenesis (United States) (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4774
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59