FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors
FADD signaling in hepatocellular carcinoma cells increases CCL5 production to generate a hot microenvironment that is responsive to immune checkpoint blockade, providing a strategy to improve immunotherapy responses in liver cancer patients.
Authors
- Jintian Chen (ORCID: https://orcid.org/0009-0006-0376-8826)
- Jingqing Li (ORCID: https://orcid.org/0000-0001-9794-1250)
- Raymond Wai Ming Lung (ORCID: https://orcid.org/0000-0002-0813-7429)
- Jingying Zhou (ORCID: https://orcid.org/0000-0002-9740-6159)
- Howard H.W. Leung (ORCID: https://orcid.org/0000-0001-9930-1783)
- Zhao-Lei Zeng (ORCID: https://orcid.org/0000-0003-4420-5625)
- Ka‐Fai To (ORCID: https://orcid.org/0000-0003-4919-3707)
- Yalin Tu (ORCID: https://orcid.org/0000-0002-6705-683X)
- Alfred S.L. Cheng (ORCID: https://orcid.org/0000-0003-2345-6951)
- Wei Kang (ORCID: https://orcid.org/0000-0002-4651-677X)
- Zhewen Xiong (ORCID: https://orcid.org/0000-0003-2679-2934)
- Yixuan Zhang (ORCID: https://orcid.org/0009-0002-8817-1746)
- Qi‐Nian Wu (ORCID: https://orcid.org/0000-0002-9771-9956)
- Man Tong (ORCID: https://orcid.org/0000-0001-5725-0391)
- Thomas Ting-Hei Chan (ORCID: https://orcid.org/0000-0001-6125-0001)
- Huanyu Wang
- Yun Wang (ORCID: https://orcid.org/0009-0009-6064-0871)
- Dan Wang (ORCID: https://orcid.org/0000-0002-5934-9085)
- Weiqin Yang (ORCID: https://orcid.org/0000-0002-3564-9104)
- Anthony W.H. Chan (ORCID: https://orcid.org/0000-0002-1771-163X)
- Jiahuan Lu (ORCID: https://orcid.org/0009-0009-5102-0347)
- Jing Wang (ORCID: https://orcid.org/0000-0002-8911-9555)
- Jingya Wang
Institutions
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3854
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00