FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors

FADD signaling in hepatocellular carcinoma cells increases CCL5 production to generate a hot microenvironment that is responsive to immune checkpoint blockade, providing a strategy to improve immunotherapy responses in liver cancer patients.

Authors

Institutions

Publication Details

Journal
Cancer Research
Published
2025-07-14
DOI
https://doi.org/10.1158/0008-5472.can-24-3854
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors

Jintian Chen, Jingqing Li, Raymond Wai Ming Lung, Jingying Zhou et al.
1 links
Cancer Research
Cancer Immunotherapy and Biomarkers
article

FADD Activation in Hepatocellular Carcinoma Potentiates CD8+ T-cell Responses and Sensitizes to Immune Checkpoint Inhibitors

Jintian Chen, Jingqing Li, Raymond Wai Ming Lung, Jingying Zhou, Howard H.W. Leung, Zhao-Lei Zeng, Ka‐Fai To, Yalin Tu, Alfred S.L. Cheng, Wei Kang, Zhewen Xiong, Yixuan Zhang, Qi‐Nian Wu, Man Tong, Thomas Ting-Hei Chan, Huanyu Wang, Yun Wang, Dan Wang, Weiqin Yang, Anthony W.H. Chan, Jiahuan Lu, Jing Wang, Jingya Wang
article en

Abstract

FADD signaling in hepatocellular carcinoma cells increases CCL5 production to generate a hot microenvironment that is responsive to immune checkpoint blockade, providing a strategy to improve immunotherapy responses in liver cancer patients.

Cancer ResearchVol. 85(18)
Sun Yat-sen University (CN), Chinese University of Hong Kong (HK), Sun Yat-sen University Cancer Center (CN)
Good health and well-being
Openalex Percentile: Top 75%
Cancer Immunotherapy and Biomarkers
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.