Effects of five cannabis oils with different CBD: THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental model
This study demonstrated that COs, particularly THC-rich CO, CBD:THC ratio 1:1 CO, CBD:THC ratio 2:1 CO and terpenes, can effectively reduce dyslipidemia, liver damage and hepatic steatosis in SRD-induced NAFLD. COs with a higher proportion of CBD in their composition showed antihypertensive properties. All the COs exhibited antioxidant properties. These findings suggest that COs, especially those with CBD:THC ratios of 1:1 and 2:1 and terpenes, may represent a promising therapeutic approach for managing NAFLD and preventing its progression to more severe liver disease.
Authors
- Valentina Degrave (ORCID: https://orcid.org/0000-0001-6605-4106)
- Marı́a Eugenia D’Alessandro
- Lucía Torregiani
- Yamile Soledad (ORCID: https://orcid.org/0000-0002-5501-3488)
- Michelle Berenice Vega Joubert (ORCID: https://orcid.org/0000-0002-8310-7844)
- Paola I. Ingaramo (ORCID: https://orcid.org/0000-0002-1117-6824)
- María Eugenia Oliva (ORCID: https://orcid.org/0000-0002-4368-4102)
- María M. De Zan (ORCID: https://orcid.org/0000-0002-2218-2322)
- Camila Filippa
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional del Litoral (AR)
- Centro Científico Tecnológico - Santa Fe (AR)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s42238-025-00286-8
- Citations
- 2
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Ministerio de Ciencia, Tecnología e Innovación Productiva