DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus
We initially revealed that P. micra was a crucial pathogen in the development of OLP and demonstrated that P. micra's EVs induce the inhibition of autophagy and enhanced TNF-α secretion in OLP fibroblasts via the DnaK-BAG3-IKK-γ axis. This study offers novel insights into the pathogenic mechanisms underlying OLP. Video Abstract.
Authors
- Xiufeng Gu
- Mengfan Zhi
- Qiang Feng (ORCID: https://orcid.org/0000-0002-4055-226X)
- Lan Xiang (ORCID: https://orcid.org/0000-0002-7149-8235)
- Xiaoli Ji (ORCID: https://orcid.org/0000-0002-2666-5946)
- Jingyuan Li (ORCID: https://orcid.org/0000-0002-2510-2893)
- Peipei Sun (ORCID: https://orcid.org/0000-0001-7130-6830)
- Ying Han (ORCID: https://orcid.org/0000-0002-6474-8283)
- Xiang-min Qi (ORCID: https://orcid.org/0000-0001-9651-8119)
- Lixiang Song
Institutions
- Shandong University (CN)
- Peking University (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s40168-025-02151-5
- Citations
- 2
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Peking University