Silent progression of hemophilic arthropathy of the elbow: case reports of three pediatric patients

We present three pediatric cases of hemophilic arthropathy (HA) of the elbow that had already progressed to advanced stage with osteochondral lesions at the time of diagnosis-Case 1: 13-year-old boy, severe hemophilia A; Case 2: 13-year-old boy, moderate hemophilia A; Case 3: 15-year-old boy, severe hemophilia A. HA results from repeated hemarthrosis. Notably, Cases 2 and 3 had no history of clinically recognized elbow hemarthrosis before HA diagnosis, and Case 1 had only two episodes of hemarthrosis. Cases 2 and 3 did not report elbow extension restriction and pain for 1 or 2 years, as their daily lives were minimally affected. Since full elbow extension or flexion is rarely needed in daily life, and restricted elbow motion can be compensated by other motions, leading to less inconvenience. Consequently, HA of the elbow often remains unnoticed until it progresses to advanced stage; which necessitates careful monitoring from childhood.

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Publication Details

Journal
Blood Coagulation & Fibrinolysis
Published
2025-07-14
DOI
https://doi.org/10.1097/mbc.0000000000001382
Primary Topic
Hemophilia Treatment and Research
Type
article
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article

Silent progression of hemophilic arthropathy of the elbow: case reports of three pediatric patients

Ryota Koyama, Naoki Haraguchi, Chiai Nagae, Atsuko Fujikawa et al.
Blood Coagulation & Fibrinolysis
Hemophilia Treatment and Research
article

Silent progression of hemophilic arthropathy of the elbow: case reports of three pediatric patients

Ryota Koyama, Naoki Haraguchi, Chiai Nagae, Atsuko Fujikawa, Yotaro Umezawa, Yuki Saito, Atsuki Yamashita, Mika Mori, Takeshi Arai, Tomoko Ashikaga, Masashi Taki
article en

Abstract

We present three pediatric cases of hemophilic arthropathy (HA) of the elbow that had already progressed to advanced stage with osteochondral lesions at the time of diagnosis-Case 1: 13-year-old boy, severe hemophilia A; Case 2: 13-year-old boy, moderate hemophilia A; Case 3: 15-year-old boy, severe hemophilia A. HA results from repeated hemarthrosis. Notably, Cases 2 and 3 had no history of clinically recognized elbow hemarthrosis before HA diagnosis, and Case 1 had only two episodes of hemarthrosis. Cases 2 and 3 did not report elbow extension restriction and pain for 1 or 2 years, as their daily lives were minimally affected. Since full elbow extension or flexion is rarely needed in daily life, and restricted elbow motion can be compensated by other motions, leading to less inconvenience. Consequently, HA of the elbow often remains unnoticed until it progresses to advanced stage; which necessitates careful monitoring from childhood.

Blood Coagulation & FibrinolysisVol. 36(6)
St. Marianna University School of Medicine (JP), Yokohama City Seibu Hospital (JP), Shonan University of Medical Sciences (JP), Yokosuka Kyosai Hospital (JP), Naval Hospital Yokosuka Japan (JP)
Peace, Justice and strong institutions
Openalex Percentile: Top 79%
Hemophilia Treatment and Research
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Silent progression of hemophilic arthropathy of the elbow: case reports of three pediatric patients — Ryota Koyama, Naoki Haraguchi, et al. · Blood Coagulation & Fibrinolysis (2025) | TGRS Research Map | TGRS