High tidal volume mechanical ventilation exacerbates pulmonary injury via upregulation of PAI-1 expression in rats
Mechanical ventilation strategies utilizing high tidal volumes were associated with substantial increases in PAI-1 expression in rat lung tissue and BALF, with these effects exacerbated by prolonged ventilation durations. These findings suggest that high tidal volume ventilation strategies may contribute to pulmonary injury by upregulating PAI-1 expression.
Authors
- G Wang
- Zhi Wang (ORCID: https://orcid.org/0000-0001-6083-9068)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0002-0431-5355)
- Jing Bi (ORCID: https://orcid.org/0000-0001-9921-9990)
- Jinbao Ren
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s41065-025-00446-z
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00