Dexamethasone, celecoxib, and simvastatin-induced 5-fluorouracil resistance in cancer cells: a possible role of lipid droplet accumulation

The findings highlight that DEX, CXB, and SMV enhance 5-FU resistance by increasing LD accumulation, highlighting a critical, previously overlooked metabolic factor that may impact clinical treatment strategies and patient outcomes. If similar effects occur in clinical settings, the use of these drugs may need to be adjusted to avoid compromising cancer treatment efficacy. Further studies are warranted to evaluate this interaction and its implications in clinical practice.