Four new alkaloids from <i>Dactylicapnos grandifoliolata</i>

The first phytochemical investigation on <i>D. grandifoliolata</i> yielded twenty-four alkaloids, including four new ones, <i>N</i>-butylacetamide magnococline (<b>1</b>), fumariflorine methyl ester (<b>6</b>), (<i>R</i>)-corydalisol-2<i>β</i>-<i>N</i>-oxide (<b>9</b>), and (<i>R</i>)-coryximine-2<i>α</i>-<i>N</i>-oxide (<b>10</b>). Among them, compound <b>1</b> was an <i>N-</i>butylacetamide-substituted benzylisoquinoline alkaloid. Compounds <b>9</b> and <b>10</b> were <i>N</i>-oxides of benzylisoquinoline alkaloids. The structures of the new alkaloids were determined through comprehensive spectroscopic analysis and ECD calculations.