Choline–geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs
The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(II) and Pt(IV) complexes was investigated. All complexes exhibited appreciable solubility in CAGE ILs, with Pt(II) complexes 2 and 4 undergoing immediate ligand substitution. In contrast, the hydrophobic derivative 3 demonstrated remarkable stability for up to 48 hours. <sup>19</sup>F-<sup>1</sup>H HOESY NMR analysis revealed that 3 localized within the hydrophobic regions of CAGE 1 : 2 (choline:geranate). When tested in U87-MG glioblastoma cells, CAGE ILs enhanced the anticancer activity of the Pt complexes. Notably, complex 3 exhibited a significant increase in cytotoxicity, nearly completely reducing cell viability when formulated with CAGE IL.
Authors
- Jose Ignacio Miranda (ORCID: https://orcid.org/0000-0002-7646-6857)
- Alba González (ORCID: https://orcid.org/0000-0003-2513-8754)
- Elena Formoso (ORCID: https://orcid.org/0000-0002-7106-3717)
- Francesca Re (ORCID: https://orcid.org/0000-0003-1374-567X)
- Elixabete Rezabal (ORCID: https://orcid.org/0000-0003-0397-6140)
- Alejandro H. Orrego (ORCID: https://orcid.org/0000-0003-4412-1579)
- Giulia Sierri (ORCID: https://orcid.org/0009-0002-1025-4103)
- Luca Salassa (ORCID: https://orcid.org/0000-0002-2112-9095)
- Francesco Saverio Sica (ORCID: https://orcid.org/0009-0003-7721-439X)
- Marta Costa Verdugo
- Laura Hernandez-Fernandez
Institutions
- Ikerbasque (ES)
- University of the Basque Country (ES)
- CIC biomaGUNE (ES)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Donostia International Physics Center (ES)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02226f
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eusko Jaurlaritza
- Ministerio de Economía y Competitividad
- Agencia Estatal de Investigación