Evaluating peripapillary vessel density and retinal nerve fiber layer thickness in pseudoexfoliation syndrome: a comparative study

PSX is driven by the excessive synthesis of elastic microfibrils and their aberrant cross-linking, leading to the deposition of this pathological material in various tissues. 5,6In the eye, the primary sites involved in the production of these microfibrillar aggregates include the iris, ciliary epithelium, corneal endothelium, lens epithelium, trabecular meshwork epithelium, and vascular endothelial cells. 6ese tissues contribute to the accumulation of PSX material, which is predominantly deposited in the lens zonules, ciliary body, lens capsule, and trabecular meshwork. 6,7 IntroductIonPseudoexfoliation syndrome (PSX) is a systemic disorder characterized by the abnormal production and accumulation of extracellular fibrillar material, which affects multiple organs and tissues throughout the body. [1][2]2][3][4][5] This condition is primarily associated with aging, as its incidence significantly increases with advancing age. 2-4Moreover, the prevalence of PSX varies greatly across different ethnic groups and geographical regions, reflecting genetic and environmental influences on its development.