Lipid infiltration promotes trans-differentiation of vascular smooth muscle cells into macrophage-like cells in early lesions of human coronary atherosclerosis
Lipid infiltration begins in the early stages of human coronary artery atherosclerotic lesions and may promote trans-differentiation of intimal SMCs into macrophage-like cells, as indicated by expression of the macrophage-associated protein FABP4. These findings provide novel insight into early atherogenesis and may help identify potential targets for timely prevention and intervention in cardiovascular disease.
Authors
- Yuanfeng Liang
- Wanwen Chen (ORCID: https://orcid.org/0000-0001-7465-8276)
- Junhai Hao (ORCID: https://orcid.org/0000-0003-4798-5727)
- Jiang Liu (ORCID: https://orcid.org/0000-0001-9845-2619)
- Jiahui Zhou
- Yueheng Wu (ORCID: https://orcid.org/0000-0002-6135-3796)
- Zhanyi Lin (ORCID: https://orcid.org/0000-0002-7114-885X)
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s12944-025-02662-y
- Citations
- 4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 8.03