Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain
This study evaluated a rigorous series of outcome measures to determine the effects of IVD injury on the disc joint and pain in a CD canine in vivo model of back pain. This was the first study to investigate the effects of disc injury on canine DRG transcriptome and whole-cell patch clamping on canine DRG neurons. Results support the CD dog as a clinically relevant translational model for studying IVDD and LBP, and for evaluating the potential efficacy of novel therapeutics in mitigating the changes associated with these conditions.
Authors
- Justin Richards (ORCID: https://orcid.org/0000-0003-4584-8614)
- Maciej Pietrzak (ORCID: https://orcid.org/0000-0001-5768-7884)
- Gilian Gunsch
- Adam B. Smith (ORCID: https://orcid.org/0000-0002-6420-1659)
- Kyle Kuchynsky
- Candice C. Askwith
- Sarah McBride‐Gagyi (ORCID: https://orcid.org/0000-0003-2652-7997)
- Mary K. Heimann (ORCID: https://orcid.org/0009-0001-9267-375X)
- Sarah A. Moore (ORCID: https://orcid.org/0000-0002-4311-6199)
- Brett Klamer (ORCID: https://orcid.org/0000-0002-8334-4831)
- Devina Purmessur (ORCID: https://orcid.org/0000-0002-7445-1678)
- Shirley Tang (ORCID: https://orcid.org/0000-0001-8807-2348)
- Benjamin A. Walter (ORCID: https://orcid.org/0000-0002-0742-5533)
- Kara N. Corps (ORCID: https://orcid.org/0000-0002-5584-6738)
- Megan Co (ORCID: https://orcid.org/0000-0003-4173-429X)
- Fangli Zhao (ORCID: https://orcid.org/0000-0003-3855-3885)
- Brad Youngblood
- Jake Klausner
- Kaitlyn Cimney
Institutions
- Ohio Department of Education (US)
- The Ohio State University (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/jsp2.70082
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ohio State University
- National Institutes of Health
- National Cancer Institute