Spectrum of Interstitial Cell of Cajal Deficits in Chronic Gastroduodenal Disorders: Systematic Review and Meta-Analysis
Marked depletion of ICC is a consistent finding in neurogastroduodenal disorders. A spectrum of disease is revealed, with greater depletion associated with delayed emptying. Techniques for clinically defining ICC-driven gastric neuromuscular dysfunction should be prioritized.
Authors
- Henry P. Parkman (ORCID: https://orcid.org/0000-0003-4904-4891)
- Gregory O’Grady (ORCID: https://orcid.org/0000-0002-5998-1080)
- Pankaj J. Pasricha (ORCID: https://orcid.org/0000-0002-8727-683X)
- Christopher N. Andrews (ORCID: https://orcid.org/0000-0002-2869-4396)
- Thomas L. Abell (ORCID: https://orcid.org/0000-0002-3175-5161)
- Armen A. Gharibans (ORCID: https://orcid.org/0000-0002-9139-4740)
- Dániel Keszthelyi (ORCID: https://orcid.org/0000-0001-9856-9980)
- Gianrico Farrugia (ORCID: https://orcid.org/0000-0003-3473-5235)
- Chris Varghese (ORCID: https://orcid.org/0000-0001-7369-8639)
Institutions
- Mayo Clinic (US)
- University of Louisville (US)
- University of Auckland (NZ)
- University of Calgary (CA)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Temple University Hospital (US)
- Mayo Clinic Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.14309/ajg.0000000000003646
- Citations
- 7
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 12.68