Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis
In this retrospective study from a single expert center, most patients with myasthenic crisis underwent intermediate or prolonged weaning, but extubation failure rate was very low. Thymoma and lack of MG-specific immunosuppressive treatment at ICU admission are associated with prolonged weaning, while age alone is not. Despite initial challenges, long-term outcomes are generally favorable, highlighting the reversibility of myasthenic crisis with expert care.
Authors
- Lucas Di Meglio (ORCID: https://orcid.org/0000-0002-5158-8612)
- Sophie Demeret (ORCID: https://orcid.org/0000-0002-0523-6472)
- Clémence Marois (ORCID: https://orcid.org/0000-0002-3266-0623)
- Alexandra Grinea
- Nicolas Weiss (ORCID: https://orcid.org/0000-0001-5155-196X)
- Thomas Rambaud (ORCID: https://orcid.org/0000-0003-1677-0838)
- Benjamin Rohaut (ORCID: https://orcid.org/0000-0001-6752-8756)
- Loïc Le Guennec (ORCID: https://orcid.org/0000-0001-8146-6256)
- Françis Bolgert
- Meriem Bouguerra (ORCID: https://orcid.org/0009-0007-5076-9060)
- Arthur Combes
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche Saint-Antoine (FR)
- Institut Cochin (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- Réanimation et soins intensifs du patient en Insuffisance respiratoire aigüe
- Imation (United States) (US)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-025-01515-2
- Citations
- 4
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 5.56