Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro
The PI3K/AKT/mTOR signalling pathway is associated with radioresistance in CRC. miR-16-5p represses pathway genes and increases radiosensitivity, suggesting that miRNA-based gene therapy may improve treatment outcomes and patient quality of life.
Authors
- Maryam Moghaddam Matin (ORCID: https://orcid.org/0000-0002-7949-7712)
- Seyed Hamid Aghaee‐Bakhtiari (ORCID: https://orcid.org/0000-0002-6093-7837)
- Hosein Azimian (ORCID: https://orcid.org/0000-0003-2951-8228)
- Seyedeh Nasibeh Mousavikia
- Mohammad Taghi Bahreyni Tossi
Institutions
- Mashhad University of Medical Sciences (IR)
- Ferdowsi University of Mashhad (IR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1186/s12885-025-14501-5
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Mashhad University of Medical Sciences