An optical/magnetic imaging nanoplatform-mediated convection-enhanced delivery of oxaliplatin for glioma treatment

Glioma is a highly lethal form of cancer, and its treatment requires overcoming several challenges, including the blood-brain barrier (BBB), rapid drug release at the tumor site, and monitoring of drug distribution. Herein, we have developed a bio-responsive optical/magnetic signal amplification nanoplatform (Gd/Cy5-Oxa@NPs) by conjugating a pH-responsive polymer block copolymer with cyanine 5 dye and then loaded this with gadolinium chloride and oxaliplatin (Oxa). The nanoplatform is administered <i>via</i> convection-enhanced delivery (CED) to hinder the progression of glioblastoma tumors. The CED of the nanoplatform offers a direct way to bypass the BBB, significantly reducing the required dosage without inducing detectable toxicity. The nanoplatform facilitates cell internalization and rapidly releases Oxa in acidic environments, enhancing treatment accuracy. <i>In vivo</i> experimental results demonstrate that the nanoplatform achieves remarkable anti-glioma efficacy through CED at low concentrations. Our research suggests that the combination of a pH-responsive optical/magnetic imaging nanoplatform and CED may represent a promising translational strategy for drug tracking and glioma treatment.