Reduced glomerular and elevated tubulointerstitial transglutaminase pathway and its inhibition in a rat model of renal warm ischemia: implications for feline chronic kidney disease

Our findings support a causal link between TG2 and tubulointerstitial fibrosis in rats following RWI. In contrast, the glomerular TG-pathway was suppressed, suggesting a protective mechanism in response to RWI, which may help to explain the lack of glomerular involvement in feline CKD. This rodent model of RWI may be analogous to feline CKD, enabling extrapolation of findings from rodent RWI models to understand renal insult in cats.