Concise Total Synthesis of Sandramycin and Its Analogues via Cyclodimerization Using Mitsunobu Reaction
Total synthesis of sandramycin was achieved via a cyclodimerization approach of the precursor pentapeptide by using the Mitsunobu reaction. This strategy allowed us to prepare a range of analogues efficiently. Their DNA binding ability and cytotoxicity against human cancer cell lines were also evaluated.
Authors
- Satoshi Ichikawa (ORCID: https://orcid.org/0000-0001-5345-5007)
- Yasuaki Tokodai (ORCID: https://orcid.org/0009-0007-5628-8962)
- Yuya Komatani (ORCID: https://orcid.org/0000-0001-5177-6587)
- Radhakrishnam Raju Ruddarraju
Institutions
- Hokkaido University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1021/acs.joc.5c01110
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00