Evaluation of effectiveness ozonized gel versus chlorhexidine gel in management of periodontal pockets in chronic periodontitis: A randomized controlled clinical trial

Background Scaling and root planing (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Objective To evaluate and compare the clinical effectiveness of ozone (OZ) and chlorhexidine (CHX) as an adjunct to SRP in patients with Stage 2 periodontitis. Methods Thirty patients with generalized moderate to severe chronic periodontitis with presence of at least one site in each quadrant with a probing depth ≥5 mm were recruited. In a split-mouth study design, bilateral pockets were randomly allocated to the SRP and OZ therapy. Plaque index (PI), gingival index (GI), probing pocket depth (PD), and clinical attachment loss (CAL) were assessed and compared for two different treatment groups at baseline and at 3 months. Results Both groups demonstrated significant intragroup reduction in PI, GI, PPD, and CAL from baseline to 3 months follow-up. There were no significant intergroup differences between two groups for PI, GI, and CAL on statistical evaluation but for PPD results were highly significant ( p < 0.05). Conclusion Ozonated gel could be used as an adjunctive chemical plaque control agent in patients with chronic periodontitis.