Antidepressant discontinuation does not cause severe symptoms in most people, study finds

The prevalence of antidepressant discontinuation symptoms is lower than clinical guidelines suggest, according to a systemic review and meta-analysis published in JAMA Psychiatry. The analysis of 29 randomised clinical trials (RCTs), published on 9 July 2025, revealed that the average number of discontinuation symptoms observed one week after patients stopped taking antidepressants was “below the […]