TOPICAL CHEMOTHERAPY AND RADIOTHERAPY TREATMENT IN BASAL CELL CARCINOMA AS AN ALTERNATIVE TO SURGICAL EXCISION

Introduction: Basal cell carcinoma (BCC) is the most prevalent form of skin cancer worldwide, and non‑surgical treatment modalities are increasingly used in cases where surgery is contraindicated or may result in poor cosmetic outcomes. Objective: To review current evidence on topical chemotherapy and radiotherapy as alternative treatments for BCC and evaluate efficacy, tolerability, cosmetic results, and potential limitations. Methods: A narrative review of studies published in the last decade was conducted, including randomized trials, cohort studies, and case series examining topical agents and radiation therapy in BCC management. Results and Discussion Topical treatments such as imiquimod and 5‑fluorouracil have demonstrated variable clearance rates, with better outcomes in superficial and small nodular BCC; radiotherapy offers high cure rates with acceptable cosmesis but has long‑term risks; comparative studies suggest both modalities are reasonable alternatives in select patients. Conclusion: Topical chemotherapy and radiotherapy present viable non‑surgical alternatives for BCC in patients unfit or unwilling for excision, but further high‑quality trials are needed to optimize treatment selection and protocols.