Synthesis of <i>N</i>-Methylated Amines via Reduction of Carbamates Using Amidophosphine Borane

A hydride transfer strategy for the synthesis of <i>N</i>-methylated primary, secondary amines, and <i>N</i>-methylated heterocyclic amines is reported. This protocol effectively converts diverse carbamates into <i>N</i>-methylated amines using bench-stable amidophosphine borane as a reducing agent. The reaction demonstrates a broad substrate scope and functional group tolerance under mild conditions. Additionally, the application of this protocol for the synthesis of pharmaceutically active butenafine analogues is shown.