Copper-Catalyzed One-Pot Cascade Reactions of CF₃CHN₂, Nitriles, and Alkenes: Chemo- and Regioselective Access to 2-(Trifluoromethyl)pyrroles

Herein, we report a facile and versatile copper-catalyzed protocol for the chemo- and regioselective synthesis of highly substituted 2-(trifluoromethyl)pyrroles from readily available starting materials. This one-pot cascade reaction of CF₃CHN₂, nitrile, and nitroalkene proceeds efficiently under mild conditions, enabling access to a broad spectrum of 2-(trifluoromethyl)pyrroles. Furthermore, the utility of this method is demonstrated by the synthesis of a series of highly substituted pyrroles bearing both trifluoromethyl and cyano groups.